Natural History of Cerebral Palsy

About the Study

The project, funded by the Cerebral Palsy Alliance, will aim to describe the early natural history of CP in infants aged 0-2 years in a large prospective longitudinal cohort. Specifically, we will determine: i. The relationship between severity of motor disability in CP and the location, extent and nature of the brain lesion on term MRI and early standardized neurological assessment HINE scores using the Hammersmith Infant Neurological Examination ii. The relationship between motor type and topography and the location and nature of the brain lesion on term MRI iii. The relationship between motor tests at 3- 4 months and gross motor function as classified by GMFCS and hand function at 2 years iv. The relationship between severe cerebral vision impairment at 3- 4 months and gross motor function as classified by GMFCS and hand function at 2 years v. The rates of hip displacement (i.e. proportion of children with hip percentage migration >30%) at 2 years following the implementation strategy compared to current practice? vi. The changes of parental mental health of infants with CP over the first two years of life.

Contact: O.Chorna ochorna@fsm.unipi.it S.Del Secco sdelsecco@fsm.unipi.it A. Guzzetta aguzzetta@fsm.unipi.it

Pisa SMILE Lab

Email: pisasmilelab@fsm.unipi.it

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